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Treatment with cultured epidermal autograft from revertant skin for epidermolytic ichthyosis

GSE245859 Homo sapiens Expression profiling by high throughput sequencing 4 samples Submitted 2024/05/22 Platform GPL24676
Summary
We performed clinical trial of treatment with cultured epidermal autograft (CEA) produced from patients’ own revertant epidermal keratinocytes as a proof-of-concept study. We successfully produced CEAs from genetically confirmed revertant skin of the three EI patients and genetically confirmed that CEAs mainly consist of revertant wild-type cells by amplicon sequencing and droplet digital PCR analysis. Single-cell RNA sequencing analysis confirmed normal proliferation and safety profiling of CEAs.
Published in
Treating epidermolytic ichthyosis and ichthyosis with confetti with epidermal autografts cultured from revertant skin
Tanahashi K, Kono M, Yoshikawa T et al. · The British journal of dermatology 2024 · PMID 38739763 · doi:10.1093/bjd/ljae193
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Direct links to NCBI, no account and no request form: the whole study as GSE245859_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 4 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1030286 and SRA study SRP467508. Searching any of these in the dataset finder brings you back here.

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