Cross-tissue human fibroblast atlas reveals myofibroblast subtypes with distinct roles in immune modulation [scRNA-seq]

Fibroblasts hold pivotal roles in tissue homeostasis and disease progression. However, a systematic study addressing the functional heterogeneity of fibroblasts, their dynamic shifts along disease progression, as well as their impact to tumor immune microenvironment is currently lacking. Here, we performed integrated analyses on fibroblasts spanning multiple tissues and disease conditions, especially cancer. Our study provides novel insights into fibroblast cell heterogeneity and highlights the potential clinical utilities of fibroblast cell subsets as therapeutic targets.