Cardiac Fibrosis in Dilated Cardiomyopathy: Transcriptomics Insights, Histological Correlations, and Organoid Model Verifications
RNA-seq (gene expression) · human · 67 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 67 samples: 58 × HhGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Integrative Transcriptomic-Histological Analysis in Dilated Cardiomyopathy Unveils FGFR1 Inhibition as Anti-Cardiac Fibrotic and Cardioprotective TherapyJACC. Basic to translational science · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE246299_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1032456 and SRA study SRP468559. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 58 samples.
How we read this: 1 replicated groups read from 67 sample titles; they account for 58 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7849647 Hh24 Hh
- GSM7849648 Hh30 Hh
- GSM7849649 Hh36 Hh
- GSM7849650 Hh38 Hh
- GSM7849651 Hh39 Hh
- GSM7849652 Hh46 Hh
- GSM7849653 Hh48 Hh
- GSM7849654 Hh51 Hh
- GSM7849655 Hh52 Hh
- GSM7849656 Hh53 Hh
- GSM7849657 Hh54 Hh
- GSM7849658 Hh55 Hh
- GSM7849659 Hh57 Hh
- GSM7849660 Hh59 Hh
- GSM7849661 Hh60 Hh
- GSM7849662 Hh62 Hh
- GSM7849663 Hh66 Hh
- GSM7849664 Hh68 Hh
- GSM7849665 Hh69 Hh
- GSM7849666 Hh71 Hh
- GSM7849667 Hh74 Hh
- GSM7849668 Hh75 Hh
- GSM7849669 Hh76 Hh
- GSM7849670 Hh80 Hh
- GSM7849672 Hh88 Hh
- GSM7849674 Hh89 Hh
- GSM7849676 Hh90 Hh
- GSM7849678 Hh93 Hh
- GSM7849680 Hh100 Hh
- GSM7849682 Hh103 Hh
- GSM7849683 Hh104 Hh
- GSM7849684 Hh111 Hh
- GSM7849685 Hh112 Hh
- GSM7849686 Hh114 Hh
- GSM7849687 Hh116 Hh
- GSM7849688 Hh118 Hh
- GSM7849689 Hh119 Hh
- GSM7849690 Hh121 Hh
- GSM7849691 Hh123 Hh
- GSM7849692 Hh125 Hh
+ 27 more — browse all 67 samples with per-sample file links →
- GSE246298 Cardiac Fibrosis in Dilated Cardiomyopathy: Transcriptomics Insights, Histological Correlations, and Organoid Model Verifications [RNA-seq II] 9 samples shares cardiomyopathy, verifications, histological, correlations, fibrosis, organoid, cardiac, dilated
- GSE245825 Cardiac Fibrosis in Dilated Cardiomyopathy: Transcriptomics Insights, Histological Correlations, and Organoid Model Verifications [RNA-seq I] 58 samples shares cardiomyopathy, verifications, histological, correlations, fibrosis, organoid, cardiac, dilated
- GSE274292 Integrative Transcriptomic and Histological Analysis in Dilated Cardiomyopathy Unveils FGFR Inhibition as a Novel Therapeutic Strategy with Anti-Cardiac Fibrosis and Cardiac Protective Effects mediated by NPR1 signaling 1 samples shares cardiomyopathy, histological, fibrosis, cardiac, dilated
- GSE261750 Cardiac fibroblast BAG3 regulates TGFBR2 signaling and fibrosis in dilated cardiomyopathy 2 samples shares cardiomyopathy, fibrosis, cardiac, dilated
- GSE262876 Cardiac Organoids for Modeling Hypertrophic Cardiomyopathy 16 samples shares cardiomyopathy, organoid, cardiac
- GSE280050 Senolytics rejuvenate aging cardiomyopathy in human cardiac organoids 15 samples shares cardiomyopathy, organoid, cardiac
- GSE312730 Simtuzumab Attenuates Loxl2-Mediated Extracellular Matrix Remodeling and Preserves Cardiac Function in LMNA Mutation-Induced Dilated Cardiomyopathy 6 samples shares cardiomyopathy, cardiac, dilated
- GSE263607 Cardiac Organoids for Cardiomyopathy 17 samples shares cardiomyopathy, organoid, cardiac
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.