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Genomic regions occupied by both RARα and VDR are involved in the convergence and cooperation of retinoid and vitamin D signaling pathways.

GSE246307 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 4 samples Submitted 2024/12/31 Platform GPL18573
Summary
In this study, the retinoid and vitamin D pathways were investigated in PMA-differentiated THP-1 cells treated with or without the RARa agonist, AM580, and/or the VDR agonist, 1,25-dihydroxyvitamin D3 (1,25-vitD or calcitriol), using global approaches. Binding regions of RARa and VDR were determined in PMA-differentiated THP-1 cells using chromatin immunoprecipitation coupled with high-throughput sequencing (ChIP-seq). The gene sets regulated by AM580 and/or 1,25-vitD were identified by RNA-sequencing (RNA-seq). The activity of the regulatory regions was determined by MED1 (a subunit of the Mediator complex) ChIP-seq and chromatin openness was measured using assay for transposase-accessible chromatin with sequencing (ATAC-seq).
Published in
Genomic regions occupied by both RARα and VDR are involved in the convergence and cooperation of retinoid and vitamin D signaling pathways
Mianesaz H, Göczi L, Nagy G et al. · Nucleic acids research 2025 · PMID 40167329 · doi:10.1093/nar/gkaf230
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Also filed as BioProject PRJNA1032482 and SRA study SRP468605. Searching any of these in the dataset finder brings you back here.

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