GCN2 is a determinant of the response to WEE1 kinase inhibition in small-cell lung cancer
RNA-seq (gene expression) · human · 18 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Topic
- Small cell lung cancerThis series is part of our curated briefing on it.
- Samples
- 18 samples: 18 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- GCN2 is a determinant of the response to WEE1 kinase inhibition in small-cell lung cancerCell reports · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE246354_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1032594 and SRA study SRP468639. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 18 sample titles: 18 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7867573 NCI-H82, DMSO, rep3, untreated
- GSM7867574 NCI-H82, DMSO, rep2, untreated
- GSM7867575 NCI-H82, DMSO, rep1, untreated
- GSM7867576 NCI-H82, AZD1775, rep1, treated
- GSM7867577 NCI-H82, AZD1775, rep2, treated
- GSM7867578 NCI-H82, AZD1775, rep3, treated
- GSM7867579 NJH29, DMSO, rep1, untreated
- GSM7867580 NJH29, DMSO, rep2, untreated
- GSM7867581 NJH29, DMSO, rep3, untreated
- GSM7867582 NJH29, AZD1775, rep1, treated
- GSM7867583 NJH29, AZD1775, rep2, treated
- GSM7867584 NJH29, AZD1775, rep3, treated
- GSM7867585 NCI-H82, AZD1775, rep1, untreated
- GSM7867586 NCI-H82, AZD1775, rep2, untreated
- GSM7867587 NCI-H82, AZD1775, rep3, untreated
- GSM7867588 NJH29, AZD1775, rep1, untreated
- GSM7867589 NJH29, AZD1775, rep2, untreated
- GSM7867590 NJH29, AZD1775, rep3, untreated
- GSE208446 Small cell lung cancer responds to inhibition of Jumonji enzyme in vitro and in vivo 90 samples same disease briefing · shares inhibition, lung
- GSE269636 Efficacy of Polo-life kinase 1 inhibitors in preclinical models of small cell lung cancer 6 samples same disease briefing · shares kinase, lung
- GSE289452 ABL Kinase Inactivation Promotes Transcription-Replication Conflicts and Compromises Replication Forks Revealing a Therapeutic Vulnerability in Metastatic Small Cell Lung Cancer 6 samples same disease briefing · shares kinase, lung
- GSE318538 Effect of KIFC1 knockdown on gene expression in H146 small-cell lung cancer cells 6 samples same disease briefing · shares small-cell, lung
- GSE329205 EZH2 inhibition reshapes 3D chromatin architecture to induce immunogenic phenotype in small cell lung cancer [RNA-Seq] 6 samples same disease briefing · shares inhibition, lung
- GSE329204 EZH2 inhibition reshapes 3D chromatin architecture to induce immunogenic phenotype in small cell lung cancer [ATAC-Seq] 6 samples same disease briefing · shares inhibition, lung
- GSE329206 EZH2 inhibition reshapes 3D chromatin architecture to induce immunogenic phenotype in small cell lung cancer [microC] 4 samples same disease briefing · shares inhibition, lung
- GSE255095 An in vivo screening platform using PDX models reveals KEAP1, USP22 and other drivers of chemoresistance in small cell lung cancer 67 samples same disease briefing · shares lung
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.