← BioTransfer GEO Dataset Finder
GEO series

Evolutionary insights reveal a new role of peptidyl arginine deiminase 2 in transcription regulation

GSE246420 Homo sapiens Expression profiling by high throughput sequencing 4 samples Submitted 2024/03/15 Platform GPL24676
Summary
Evolutionary insights reveal a new role of peptidyl arginine deiminase 2 in transcription regulationA systematic evolutionary analysis identified positively selected residues in the non-catalytic domain of PADI2. We established a link between the positive evolution of key residues in the PADI2 and their role in transcription. Specifically, we identified the structurally exposed loop encompassing the positively selected L162 in the PADI2 middle domain and its role in transcription and cellular proliferation. This loop contributes to the PADI2 interaction with the P-TEFb complex and cellular proliferation. Our results showcase the use of combining evolutionary and experimental approaches to dissect the dynamic of evolutionary processes.
Published in
Evolutionary analysis reveals the role of a non-catalytic domain of peptidyl arginine deiminase 2 in transcriptional regulation
Villanueva-Cañas JL, Fernandez-Fuentes N, Saul D et al. · iScience 2024 · PMID 38623337 · doi:10.1016/j.isci.2024.109584
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE246420_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 4 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1032907 and SRA study SRP468814. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 4 more — browse all 4 samples with per-sample file links →

Similar datasets

Search all human RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.