Cockayne syndrome mice reflect human kidney disease and are defective in de novo NAD biosynthesis
RNA-seq (gene expression) · mouse · 28 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 28 samples: 8 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Cockayne syndrome mice reflect human kidney disease and are defective in de novo NAD biosynthesisCell death and differentiation · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE246444_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1032941 and SRA study SRP468896. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 28 samples.
How we read this: 8 replicated groups read from 28 sample titles; they account for 28 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7868966 WT CSB, Fem Rep1 WT CSB, Fem
- GSM7868967 WT CSB, Fem Rep2 WT CSB, Fem
- GSM7868968 WT CSB, Fem Rep3 WT CSB, Fem
- GSM7868969 CSBm/m, Fem Rep1 CSBm/m, Fem
- GSM7868970 CSBm/m, Fem Rep2 CSBm/m, Fem
- GSM7868971 CSBm/m, Fem Rep3 CSBm/m, Fem
- GSM7868972 WT CSB, Male Rep1 WT CSB, Male
- GSM7868973 WT CSB, Male Rep2 WT CSB, Male
- GSM7868974 WT CSB, Male Rep3 WT CSB, Male
- GSM7868975 CSBm/m, Male Rep1 CSBm/m, Male
- GSM7868976 CSBm/m, Male Rep2 CSBm/m, Male
- GSM7868977 CSBm/m, Male Rep3 CSBm/m, Male
- GSM7868978 WT CSA, Fem Rep1 WT CSA, Fem
- GSM7868979 WT CSA, Fem Rep2 WT CSA, Fem
- GSM7868980 WT CSA, Fem Rep3 WT CSA, Fem
- GSM7868981 WT CSA, Fem Rep4 WT CSA, Fem
- GSM7868982 HO CSA, Fem Rep1 HO CSA, Fem
- GSM7868983 HO CSA, Fem Rep2 HO CSA, Fem
- GSM7868984 HO CSA, Fem Rep3 HO CSA, Fem
- GSM7868985 HO CSA, Fem Rep4 HO CSA, Fem
- GSM7868986 WT CSA, Male Rep1 WT CSA, Male
- GSM7868987 WT CSA, Male Rep2 WT CSA, Male
- GSM7868988 WT CSA, Male Rep3 WT CSA, Male
- GSM7868989 HO CSA, Male Rep1 HO CSA, Male
- GSM7868990 HO CSA, Male Rep2 HO CSA, Male
- GSM7868991 HO CSA, Male Rep3 HO CSA, Male
- GSM7868992 HO CSA, Male Rep4 HO CSA, Male
- GSM7868993 HO CSA, Male Rep5 HO CSA, Male
- GSE261869 NAD+ prevents chronic kidney disease by activating renal tubular metabolism - bulk RNA-sequencing 32 samples shares nad, kidney
- GSE264317 Changes in tryptophan de novo NAD synthesis associated with chronic intestinal inflammation 20 samples shares nad, novo
- GSE55485 Defective Mitophagy in XPA via PARP1 activation and NAD+/SIRT1-depletion: Implications for neurodegeneration (mouse) 12 samples shares nad, defective
- GSE278555 Suppression of endothelial ceramide de novo biosynthesis contributes to cardiometabolic diseases 12 samples shares biosynthesis, novo
- GSE304104 Genetic and sex-specific regulation of mitochondrial function in gonadal and inguinal adipose tissue 141 samples shares nad
- GSE330309 Impact of Sex Chromosomes and Gonad Type in Stress Susceptibility in Corticostriatal Brain Regions 96 samples shares nad
- GSE291544 Roles of chromosomal and gonadal sex in the fetal and placental responses to maternal food restriction in mice [junctional zone/decidua] 60 samples shares nad
- GSE285453 Roles of chromosomal and gonadal sex in the fetal and placental responses to maternal food restriction in mice 60 samples shares nad
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.