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Transcriptomic profiling in NAT10 knockdown acute myeloid leukemia cells

GSE246503 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2024/08/26 Platform GPL24676
Summary
RNA modification represents an important post-transcriptional regulatory mechanism in acute myeloid leukemia (AML), however the function and mechanism of RNA acetylation ac4C in AML remains elusive. Here, we report that NAT10, as the ac4C writing enzyme, plays a critical oncogenic function in AML and represents a promising therapeutic target for AML. To determine the impact of NAT10-mediated ac4C on gene expression, we conducted high throughput RNA-sequencing (RNA-seq) in NAT10-knockdown and control MOLM13 cells.
Published in
NAT10-mediated mRNA N(4)-acetylcytidine reprograms serine metabolism to drive leukaemogenesis and stemness in acute myeloid leukaemia
Zhang S, Huang F, Wang Y et al. · Nature cell biology 2024 · PMID 39506072 · doi:10.1038/s41556-024-01548-y
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Also filed as BioProject PRJNA1033530 and SRA study SRP469086. Searching any of these in the dataset finder brings you back here.

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