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Transcriptional regulation of KCNA2 coding Kv1.2 by EWS::FLI1: involvement in controlling the YAP/Hippo signalling pathway and cell proliferation

GSE246854 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2024/12/19 Platform GPL24676
Summary
Ewing sarcoma (ES), the second main pediatric bone sarcoma, is characterised by a chromosomal translocation leading to the formation of fusion proteins like EWS::FLI1. While several studies have shown that potassium channels drive the development of many tumours, limited data exist on ES. This work therefore aimed to study the transcriptional regulation of KCNA2 and define the involvement of the Kv1.2 channel encoded by KCNA2 in a key function of ES development, cell proliferation.
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Transcriptional regulation of KCNA2 coding Kv1.2 by EWS::FLI1: involvement in controlling the YAP/Hippo signalling pathway and cell proliferation
Dupuy M, Postec A, Mullard M et al. · Cell communication and signaling : CCS 2024 · PMID 39695664 · doi:10.1186/s12964-024-01981-4
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Also filed as BioProject PRJNA1034998 and SRA study SRP469853. Searching any of these in the dataset finder brings you back here.

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