m1A inhibition fuels oncolytic virus-elicited antitumor immunity via downregulating PD-L1 expression
RNA-seq (gene expression) · human · 18 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 18 samples: 6 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- m(1)A inhibition fuels oncolytic virus-elicited antitumor immunity via downregulating MYC/PD-L1 signalingInternational journal of oral science · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE247024_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1035770 and SRA study SRP470182. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 18 samples.
How we read this: 6 replicated groups read from 18 sample titles; they account for 18 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7882247 CAL-27, shCtrl, PBS, rep1 CAL-27, shCtrl, PBS,
- GSM7882248 CAL-27, shCtrl, PBS, rep2 CAL-27, shCtrl, PBS,
- GSM7882249 CAL-27, shCtrl, PBS, rep3 CAL-27, shCtrl, PBS,
- GSM7882250 CAL-27, sh61A, PBS, rep1 CAL-27, sh61A, PBS,
- GSM7882251 CAL-27, sh61A, PBS, rep2 CAL-27, sh61A, PBS,
- GSM7882252 CAL-27, sh61A, PBS, rep3 CAL-27, sh61A, PBS,
- GSM7882253 CAL-27, shCtrl, IFNγ, rep1 CAL-27, shCtrl, IFNγ,
- GSM7882254 CAL-27, shCtrl, IFNγ, rep2 CAL-27, shCtrl, IFNγ,
- GSM7882255 CAL-27, shCtrl, IFNγ, rep3 CAL-27, shCtrl, IFNγ,
- GSM7882256 CAL-27, sh61A, IFNγ, rep1 CAL-27, sh61A, IFNγ,
- GSM7882257 CAL-27, sh61A, IFNγ, rep2 CAL-27, sh61A, IFNγ,
- GSM7882258 CAL-27, sh61A, IFNγ, rep3 CAL-27, sh61A, IFNγ,
- GSM7882259 WSU-HN6, shCtrl, rep1 WSU-HN6, shCtrl,
- GSM7882260 WSU-HN6, shCtrl, rep2 WSU-HN6, shCtrl,
- GSM7882261 WSU-HN6, shCtrl, rep3 WSU-HN6, shCtrl,
- GSM7882262 WSU-HN6, sh61A, rep1 WSU-HN6, sh61A,
- GSM7882263 WSU-HN6, sh61A, rep2 WSU-HN6, sh61A,
- GSM7882264 WSU-HN6, sh61A, rep3 WSU-HN6, sh61A,
- GSE303446 Beyond CD30 Targeting: Brentuximab Vedotin Triggers Immunogenic Cell Death and Antitumor Immunity in Mycosis Fungoides, Overcoming Resistance via BCL2 Inhibition 13 samples shares inhibition, antitumor, immunity
- GSE306800 Extracellular matrix-myCAF signatures correlate with resistance to neoadjuvant aPD-L1 immune checkpoint inhibition with durvalumab + metformin in HPV+ HNSCC 18 samples shares pd-l1, inhibition
- GSE312942 Inhibition of METTL3 by STC-15 induces RNA misprocessing that results in dsRNA formation and activates innate immunity [RNA-seq] 36 samples shares inhibition, immunity
- GSE313114 Inhibition of METTL3 by STC-15 induces RNA misprocessing that results in dsRNA formation and activates innate immunity [RNA-Seq dose_response] 21 samples shares inhibition, immunity
- GSE325471 The CDK4/6 inhibitor dalpiciclib augments the antitumor efficacy of enzalutamide in preclinical models of castration-resistant prostate cancer through inhibition of MCM4-mediated DNA replication 12 samples shares inhibition, antitumor
- GSE281320 DNMT3B promotes neuroblastoma growth and survival, and its inhibition demonstrates antitumor effects. 6 samples shares inhibition, antitumor
- GSE319722 Spatial dynamics links PD-L1 and Tumor-Associated Macrophage–Enriched Niches to Immune and Mesenchymal States in microsatellite stable colorectal cancer 117 samples shares pd-l1
- GSE286827 4-1BB+ Tregs and inhibitory progenitor exhausted T cells confer resistance to anti-PD-L1 and anti-CTLA-4 combination therapy 87 samples shares pd-l1
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.