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Effect of depletion of Ku70 on gene expression profiles of murine regulatory T cells in lung tumor microevnronment

GSE247031 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2024/11/04 Platform GPL23479
Summary
The functions of the DNA repair protein Ku70 in immune homeostasis and tumor immunity remain unexplored. Here, we conducted deep sequencing of mRNA profiles from tumor-infiltrating Treg cells (from Foxp3Cre and Xrcc6fl/fl;Foxp3Cre mice injected with Lewis lung carcinoma cells). By comparing gene expression profiles, we found that Ku70-absent Treg displayed activated pathways in response to inflammatory factors and upregulated expression of genes negatively regulated by Foxp3. These findings strongly indicate that Ku70 plays a supportive role in enhancing Foxp3 transcriptional activity.
Published in
Nonclassical action of Ku70 promotes Treg-suppressive function through a FOXP3-dependent mechanism in lung adenocarcinoma
Huang Q, Tian N, Zhang J et al. · The Journal of clinical investigation 2024 · PMID 39446493 · doi:10.1172/JCI178079
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Also filed as BioProject PRJNA1035787 and SRA study SRP470195. Searching any of these in the dataset finder brings you back here.

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