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Novel function of U7 snRNA in the repression of HERV1/LTR12s and lincRNAs in human cells

GSE247500 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2024/08/29 Platform GPL16791
Summary
U7 snRNA is part of the U7 snRNP complex, required for the 3' end processing of replication-dependent histone pre-mRNAs in S phase of the cell cycle. Here, we show that U7 snRNA plays another function in inhibiting the expression of a subset of human endogenous retroviruses of HERV1/LTR12 class and LTR12-containing long intergenic noncoding RNAs (lincRNAs), both bearing sequence motifs that perfectly match the 5’ end of U7 snRNA. We demonstrate that U7 snRNA inhibits HERV1/LTR12 and lincRNA transcription and propose a mechanism in which U7 snRNA hampers the binding/activity of the NF-Y transcription factor to CCAAT motifs within LTR12 elements. Thereby, U7 snRNA plays a protective role in maintaining the silencing of deleterious genetic elements in selected types of cells. In turn, the expression of U7-dependent HERV1/LTR12s and lincRNAs seems to be relevant during early spermatogenesis in testis, where their synthesis is highly upregulated.
Published in
Novel function of U7 snRNA in the repression of HERV1/LTR12s and lincRNAs in human cells
Plewka P, Szczesniak MW, Stepien A et al. · Nucleic acids research 2024 · PMID 39189459 · doi:10.1093/nar/gkae738
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Also filed as BioProject PRJNA1038798 and SRA study SRP471283. Searching any of these in the dataset finder brings you back here.

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