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Molecular mechanisms of BCAT1 in ASK120067-resistant NSCLC cells

GSE247584 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2024/08/15 Platform GPL24676
Summary
To investigate the mechanism of BCAT1 in mediating resistance to third-generation EGFR-TKI, we employed RNA-seq analysis to compare the transcriptome signature of ASK120067-resistant NSCLC cells with or without BCAT1 knockdown. Here, gene set enrichment (GSEA) revealed a significant decrease in the expression of genes in glycolysis pathway following small interfering RNA (siRNA)-mediated BCAT1 knockdown, which indicated the role for BCAT1 in supporting TKI resistance through upregulation of glycolysis.
Published in
Branched-chain amino acid transaminase 1 confers EGFR-TKI resistance through epigenetic glycolytic activation
Zhang T, Pan Z, Gao J et al. · Signal transduction and targeted therapy 2024 · PMID 39143065 · doi:10.1038/s41392-024-01928-8
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Also filed as BioProject PRJNA1039771 and SRA study SRP471551. Searching any of these in the dataset finder brings you back here.

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