Bulk RNA-seq analysis for knockdowns of dopamine receptors DRD3 or DRD4 in JURL-MK1 cells +/- TKI (nilotinib) in vitro.
RNA-seq (gene expression) · human · 43 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 43 samples
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE247826_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1040793 and SRA study SRP472212. Searching any of these in the dataset finder brings you back here.
The sample list for this study is not cached yet. Press Load samples and it will be fetched from NCBI.
+ 43 more — browse all 43 samples with per-sample file links →
- GSE247828 Bulk RNA-seq analysis of nilotinib resistant JURL-MK1 cells compared against parental JURL-MK1 cells. 6 samples shares jurl-mk1, nilotinib
- GSE252799 Zongertinib (BI01810631), an irreversible HER2 TKI, spares EGFR signaling and improves therapeutic response in preclinical models and patients with HER2-driven cancers 90 samples shares tki
- GSE311200 Comprehensive analysis of the correlation between circulating biomarkers and tumor-immune microenvironment in advanced or recurrence non-small cell lung cancer in various treatment options, i.e., immunotherapy, EGFR TKI, and chemotherapy 41 samples shares tki
- GSE254485 Epigenetic priming promotes acquisition of TKI resistance and oncogene amplification in human lung cancer [RNA-seq] 22 samples shares tki
- GSE294147 Blocking the transfer of damaged mitochondria from cancer cells to RGS5+ MYL9+ CAFs reduces persistent tolerance to TKIs in EGFR-mutant lung cancer 18 samples shares tki
- GSE277007 Effects of magnolin and chloroform parts of Flos Magnoliae on gene expression in NCI-H1975 cells,and genetic changes after EGFR TKI resistance 16 samples shares tki
- GSE261830 RNA-seq of RET-aberrant cancer cell lines treated with RET-TKI selpercatinib 12 samples shares tki
- GSE314455 Mycoplasma infection drives EGFR-TKI resistance through convergent transcriptomic reprogramming in non-small cell lung cancer 8 samples shares tki
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.