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Total flavone of Abelmoschus manihot Lmedic inhibits the metastasis of colorectal cancer cells via inhibition of the STAT3/EMT signaling pathway by up-regulating LncRNAAL137782

GSE248066 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/11/17 Platform GPL24676
Summary
Total flavone of Abelmoschus manihot Lmedic (TFA) is a natural compound known for its anti-inflammatory, analgesic, and antioxidant properties. Despite extensive investigations into the therapeutic potential of TFA, there remains a paucity of reports regarding its impact on cancer treatment. This study aimed to elucidate the effects and mechanisms of TFA in CRC therapy. Subsequently, we employed RNA-seq technology to scrutinize differences in the gene expression profiles between TFA-treated and untreated CRC cells. Our findings underscore that TFA suppresses the growth, migration, and apoptosis of CRC cells. In animal models, TFA inhibits CRC cell growth and reduces hepatic metastasis. Mechanistically, we observed that TFA accomplishes this by upregulating long non-coding RNA AL137782, which, in turn, inhibits the EMT/STAT3 signaling pathway.
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Also filed as BioProject PRJNA1041714 and SRA study SRP472502. Searching any of these in the dataset finder brings you back here.

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