GEO series
NAD+ metabolism restriction boosts high-dose melphanan efficacy in multiple myeloma patients
GSE248379
Homo sapiens
Expression profiling by high throughput sequencing
20 samples
2024/12/24
GPL24676
Summary
A novel strategy to hinder the progression of multiple myeloma involves inhibiting NAD+ production. While solely targeting the NAMPT enzyme proved ineffective, the Preiss-Handler pathway, especially NAPRT1, emerged as pivotal in rescuing cancer cells. Cells lacking NAPRT1 become more susceptible to oxidative stress, and the dual targeting of NAMPT/NAPRT1 increased the efficacy of chemotherapy in multiple myelom.
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Paper (PMID 39661983) ↗
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