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Targeting adipocyte ESRRA promotes osteogenesis and vascular formation in adipocyte-rich bone marrow

GSE248799 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2024/03/07 Platform GPL24247
Summary
Extensive bone marrow adipocytes (BMAds) accumulation occurring under diverse pathophysiological conditions leads to bone deterioration.Estrogen-related receptor α (ESRRA) is a key regulator responding to metabolic stress.To explore the transcriptional role of ESRRA in regulating BMAds autonomous genes,bulk RNA-seq transcriptome analysis was performed in adipocyte-specific ESRRA deficiency BMAds lineage cells at 7 days upon adipogenic induction.
Published in
Targeting adipocyte ESRRA alleviates osteoarthritis via interrupting inter-organelle crosstalk of complement C3-CFD-MAC cascade
Huang T, Wang Z, Gao L et al. · Bone research 2026 · PMID 42056078 · doi:10.1038/s41413-026-00527-3
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Also filed as BioProject PRJNA1046038 and SRA study SRP474625. Searching any of these in the dataset finder brings you back here.

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