GEO series
Effect of SMARCA4 knockdown on senescent IMR90 ER:RAS cells
GSE249064
Homo sapiens
Expression profiling by high throughput sequencing
29 samples
2024/09/19
GPL30173
Summary
We report the analysis of RNA sequencing aimed at understanding the effects induced by the knockdown of various target genes on senescent cells. These genes were initially identified through a genetic screening process designed to locate regulators responsible for upregulating SASP. Specifically, we focus on exploring the repercussions of SMARCA4 knockdown, a constituent of the SWI/SNF complex subunit, on the SASP and immune responses within senescent cells. The findings will help characterise the role of SMARCA4 inhibition on senescence surveillance by Natural Killer cells.
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Paper (PMID 39813356) ↗
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