H3K36 methylation regulates cell plasticity and regeneration in the intestinal epitheliumm (RNA-seq IV)
DNA methylation · mouse · 12 samples
- What it is
- DNA methylationChemical marks on DNA that help switch genes on or off.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 6 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- H3K36 methylation regulates cell plasticity and regeneration in the intestinal epitheliumNature cell biology · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE249088_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for beta-value tables or raw IDAT files among the supplementary files.
Also filed as BioProject PRJNA1047145 and SRA study SRP475166. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 6 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7926140 Ent, rep1 Ent,
- GSM7926141 Ent, rep2 Ent,
- GSM7926142 lgr5, rep1 lgr5,
- GSM7926143 lgr5, rep2 lgr5,
- GSM7926144 Pan, rep1 Pan,
- GSM7926145 Pan, rep2 Pan,
- GSM7926146 Tuft, rep1 Tuft,
- GSM7926147 Tuft, rep2 Tuft,
- GSM7926148 EE, rep1 EE,
- GSM7926149 EE, rep2 EE,
- GSM7926150 Gob, rep1 Gob,
- GSM7926151 Gob, rep2 Gob,
- GSE275296 H3K36 methylation regulates cell plasticity and regeneration in the intestinal epithelium [cutandtag_enzyme_profiling] 12 samples shares h3k36, regeneration, methylation, plasticity, intestinal
- GSE292282 H3K79 methylation and H3K36 trimethylation synergistically regulate gene expression in pluripotent stem cells [RNA-Seq] 44 samples shares h3k36, methylation, rna-seq
- GSE294963 In Vitro Modeling of Age-Related Methylation Changes with Intestinal Organoids [RNA-Seq] 11 samples shares methylation, intestinal, rna-seq
- GSE243566 Systematic perturbations of SETD2, NSD1, NSD2, NSD3 and ASH1L reveal their distinct contributions to H3K36 methylation 125 samples shares h3k36, methylation
- GSE292289 H3K79 methylation and H3K36 trimethylation synergistically regulate gene expression in pluripotent stem cells 94 samples shares h3k36, methylation
- GSE166225 Inference of emergent spatio-temporal processes from single-cell sequencing reveals feedback between de novo DNA methylation and chromatin condensates [RNA-seq] 288 samples shares methylation, rna-seq
- GSE296993 H3K9 di-methylation dynamics underlies mouse minor zygotic genome activation [RNA-seq of mESC] 50 samples shares methylation, rna-seq
- GSE226579 Stem Cell Activity-Coupled Suppression of Endogenous Retrovirus Governs Adult Tissue Regeneration [RNA-seq] 47 samples shares regeneration, rna-seq
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.