GEO series
Targeting neuronal FTL1 rescues cognitive impairments in aging
GSE249105
Mus musculus
Expression profiling by high throughput sequencing
25 samples
2025/07/08
GPL24247
Summary
Understanding cellular and molecular drivers of age-related cognitive decline is necessary to identify targets to restore cognition at old age. Here we report that ferritin light chain 1 (FTL1) is a pro-aging neuronal factor that impairs cognition. Targeting neuronal FTL1 in the hippocampi of aged mice elicits synaptic and metabolic-related molecular changes and rescues cognitive impairments. Our data identify neuronal FTL1 as a key molecular mediator of cognitive rejuvenation.
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Paper (PMID 40830655) ↗
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