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Dishevelled-1 regulates global transcriptomic changes in MDA-MB-231 triple negative breast cancer cells (ChIP-Seq).

GSE249320 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 9 samples Submitted 2024/08/30 Platform GPL18460
Summary
Dishevelled (DVL) is a crucial component of the Wnt-signaling pathway and is vital for multiple physiological processes. Previously thought to have a primarily cytoplasmic role, the discovery of DVL translocation to the nucleus reframed how DVL is viewed functionally. Despite our advances in elucidating DVL nuclear function, further investigation is needed to determine its transcriptomic and epigenetic regulatory abilities. We show here that modification of DVL1 expression globally affects the transcriptomic landscape. Additionally, analysis of DVL1 ChIP-seq allowed us to map global binding sites and reveal the extensive reach of DVL1 binding sites. Integration of RNA-Sequencing and ChIP-Sequencing further revealed DVL1 transcription factor binding partners to regulate gene expression. These findings provide insight to nuclear DVL1 regulation of gene transcription.
Published in
Dishevelled-1 regulates global transcriptomic changes and associates with ETS1 transcription factor
Martinez-Marin D, Sharma M, van Wunnik JC et al. · Nature communications 2025 · PMID 40628704 · doi:10.1038/s41467-025-61551-1
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Direct links to NCBI, no account and no request form: the whole study as GSE249320_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 9 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1048520 and SRA study SRP475750. Searching any of these in the dataset finder brings you back here.

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