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Bone marrow HSPCs differentiate into myeloid cells in depression

GSE249396 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2024/12/01 Platform GPL24247
Summary
It has been known that the numbers of neutrophils and Ly6Chi monocytes are increased in the blood of patients with depression. To better understand how HSPCs sense and adapt disease progression in depression, we used single-cell RNA sequencing (scRNA-seq) to characterize HSPCs in bone marrow from mice models of depression induced by chronic restraint stress (CRS) and chronic unpredictable mild stress (CUMS).We found that bone marrow hematopoiesis was substantially rewired toward myeloid lineages in depression, accompanied by an increase of myeloid score in bone marrow HSPCs, suggesting myeloid biased cell production in bone marrow of depressed mice.
Published in
Vasopressin drives aberrant myeloid differentiation of hematopoietic stem cells, contributing to depression in mice
Mou R, Ma J, Ju X et al. · Cell stem cell 2024 · PMID 39442524 · doi:10.1016/j.stem.2024.09.018
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Also filed as BioProject PRJNA1048970 and SRA study SRP475975. Searching any of these in the dataset finder brings you back here.

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