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GATA2 upregulation restores androgen receptor chromatin association and advances darolutamide resistance in prostate cancer (ChIP-Seq)

GSE249435 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 8 samples Submitted 2024/12/31 Platform GPL24676
Summary
Darolutamide is the latest FDA-approved antiandrogen for the treatment of metastatic prostate cancer. Despite its efficacy in prolonging disease-free survival, drug resistance invariably develops. This study aims to understand the molecular mechanisms underlying darolutamide resistance and identify potential therapeutic targets for overcoming the resistance.
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Direct links to NCBI, no account and no request form: the whole study as GSE249435_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 8 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1049035 and SRA study SRP476035. Searching any of these in the dataset finder brings you back here.

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