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Mediator kinase inhibition suppresses hyperactive interferon signaling in Down syndrome II

GSE249549 Homo sapiens Expression profiling by high throughput sequencing; Other 4 samples Submitted 2024/09/01 Platform GPL30173
Summary
Individuals with Down syndrome have a increased likelihood of suffering from inflammatory and autoimmune conditions, due to the presence of four interferon receptors on chromosome 21. Transcription of genes plays a key role in the interferon response, and the Mediator kinases, CDK8 and CDK19, are essential in potentiating this transcription. Given the role CDK8/19 play in the interferon response, and the fact that selective inhibitors of these kinases exist (such as Cortistatin A), it is possible that targetting Mediator kinase activity may alleviate symptoms of chronic inflammation in Down syndrome.
Published in
Mediator kinase inhibition suppresses hyperactive interferon signaling in Down syndrome
Cozzolino KA, Sanford L, Hunter S et al. · eLife 2025 · PMID 39928031 · doi:10.7554/eLife.100197
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Also filed as BioProject PRJNA1049466 and SRA study SRP476306. Searching any of these in the dataset finder brings you back here.

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