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Immunotherapy with natural conventional type-1 dendritic cells excels at immune memory induction to eradicate cancer relapse

GSE249585 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2025/02/03 Platform GPL21103
Summary
The potential of dendritic cell (DC) vaccination against cancer is not fully achieved. While next generation vaccines using adoptive transfer of natural DCs are explored, little is known about the precise nature of the anti-cancer immune response triggered by different natural DC subsets and their relevance in preventing postsurgical tumor recurrence. Here, we used mouse splenic conventional DC1s (cDC1s) or cDC2s pulsed with tumor cell lysates to generate DC vaccines. cDC1-based vaccination induced a stronger effector and memory CD4+ and CD8+ anti-tumor T cell response, leading to a better control of tumors treated either therapeutically or prophylactically. Using an experimental model of tumor relapse, we showed that adjuvant or neoadjuvant cDC1 vaccination improved anti-tumor immune memory, particularly by increasing the infiltrates of CD4+ tissue resident memory T cells. This translated into complete prevention of tumor relapses. Our findings suggest that cDC1-based vaccination excels at immune memory induction and prevention of cancer recurrence.
Published in
Immunotherapy with conventional type-1 dendritic cells induces immune memory and limits tumor relapse
Heras-Murillo I, Mañanes D, Munné P et al. · Nature communications 2025 · PMID 40204706 · doi:10.1038/s41467-025-58289-1
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Direct links to NCBI, no account and no request form: the whole study as GSE249585_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 4 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1049770 and SRA study SRP476424. Searching any of these in the dataset finder brings you back here.

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