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Transcriptional changes of the extracellular matrix in chronic thromboembolic pulmonary hypertension governs right ventricle remodeling and recovery [ext327_rnaseq]

GSE249694 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2024/04/18 Platform GPL30173
Summary
The present prospective study included a total number of 3 patients with a final diagnosis of chronic thromboembolic pulmonary hypertension (CTEPH), who were treated by pulmonary endarterectomy (PEA) at the Kerckhoff Heart and Thorax Center between 2016 and 2020. Biopsies of the myocardial interventricular septum from 3 patients were collected at baseline (BL) before PEA surgery (pre-septal-PEA) In this case, to account for technical and safety aspects, the specimens were taken from the myocardial interventricular septum. The aim of the Study was a comparative characterization of RNA-profiles of septum in CTEPH patients after PEA surgery (postPEA) compared to before PEA surgery (pre-septal-PEA).
Published in
Transcriptional changes of the extracellular matrix in chronic thromboembolic pulmonary hypertension govern right ventricle remodeling and recovery
Jafari L, Wiedenroth CB, Kriechbaum SD et al. · Nature cardiovascular research 2025 · PMID 40615581 · doi:10.1038/s44161-025-00672-8
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Also filed as BioProject PRJNA1050207 and SRA study SRP476676. Searching any of these in the dataset finder brings you back here.

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