PRICKLE4 Underlies IDH mutant Tumors Resistance against PARP Inhibition
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 12 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Prickle4 Drives Microenvironmental Remodeling and Resistance to Parp Inhibition in IDH-Mutant GliomaAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE249818_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1050787 and SRA study SRP477182. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 12 sample titles: 12 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7965362 IDHmut glioma, ctrl-1, Day9
- GSM7965363 IDHmut glioma, ctrl-2, Day9
- GSM7965364 IDHmut glioma, ctrl-3, Day9
- GSM7965365 IDHmut glioma, lenvatinib-1, Day9
- GSM7965366 IDHmut glioma, lenvatinib-2, Day9
- GSM7965367 IDHmut glioma, lenvatinib-3, Day9
- GSM7965368 IDHmut glioma, veliparib-1, Day9
- GSM7965369 IDHmut glioma, veliparib-2, Day9
- GSM7965370 IDHmut glioma, veliparib-3, Day9
- GSM7965371 IDHmut glioma, combo-1, Day9
- GSM7965372 IDHmut glioma, combo-2, Day9
- GSM7965373 IDHmut glioma, combo-3, Day9
- GSE265829 Mutant IDH1 inhibition activates tumor immunity via endogenous reverse transcriptase and dsDNA sensing 21 samples shares idh, inhibition, mutant
- GSE264725 Mutant IDH1 inhibition induces dsDNA sensing to activate tumor immunity [mouse_glioma_rnaseq] 12 samples shares idh, inhibition, mutant
- GSE266686 Mutant IDH1 inhibition induces dsDNA sensing to activate tumor immunity [ChIP-Seq] 32 samples shares idh, inhibition, mutant
- GSE290828 Harnessing STING Signaling and Natural Killer Cells to overcome PARP Inhibitor Resistance in Homologous Recombination Repair altered Breast Cancer [RNA-seq] 20 samples shares parp, resistance
- GSE300887 Sequential Platinum and PARP Inhibition Enhances PD1 Immunotherapy Efficacy in Murine Brca2 Mutated Pancreatic Cancer [RNAseq_1] 13 samples shares parp, inhibition
- GSE293819 Monitoring systemic immune responses to checkpoint inhibition in breast cancer reveals host responses and mechanisms of resistance 142 samples shares resistance, inhibition
- GSE281467 Coactivation of innate immune suppressive cells induces acquired resistance against cancer immunotherapy targeting the innate immune system [TIICs RNA-seq] 30 samples shares resistance, against
- GSE281466 Coactivation of innate immune suppressive cells induces acquired resistance against cancer immunotherapy targeting the innate immune system [TME RNA-seq] 18 samples shares resistance, against
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.