Antiandrogen treatment endows ZMYDN8 dependent epigenetic reprogramming to orchestrate neuroendocrine tumor transdifferentiation
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 40 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 40 samples: 12 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE249890_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1051080 and SRA study SRP477361. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 25 samples.
How we read this: 12 replicated groups read from 40 sample titles; they account for 25 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7966520 ATAC_EV
- GSM7966521 ATAC_ZMYND8oe
- GSM7966522 EVZ8
- GSM7966523 Z8Z8
- GSM7966524 day0_ctrl1 day0_ctrl
- GSM7966525 day0_ctrl2 day0_ctrl
- GSM7966526 day0_oe1 day0_oe
- GSM7966527 day0_oe2 day0_oe
- GSM7966528 day3_ctrl1 day3_ctrl
- GSM7966529 day3_ctrl2 day3_ctrl
- GSM7966530 day3_oe1 day3_oe
- GSM7966531 day3_oe2 day3_oe
- GSM7966532 day30_ctrl1 day30_ctrl
- GSM7966533 day30_ctrl2 day30_ctrl
- GSM7966534 day30_oe1 day30_oe
- GSM7966535 day30_oe2 day30_oe
- GSM7966536 Css_siFM1_1 Css_siFM1
- GSM7966537 Css_siFM1_2 Css_siFM1
- GSM7966538 Css_Z8_siFM1_1 Css_Z8_siFM1
- GSM7966539 Css_Z8_siFM1_2 Css_Z8_siFM1
- GSM7966540 Css_DMSO_1 Css_DMSO
- GSM7966541 Css_DMSO_2 Css_DMSO
- GSM7966542 Css_inhibitor_1 Css_inhibito
- GSM7966543 Css_inhibitor_2 Css_inhibito
- GSM7966544 Css_Z8_DMSO_1 Css_Z8_DMSO
- GSM7966545 Css_Z8_DMSO_2 Css_Z8_DMSO
- GSM7966546 Css_Z8__inhibitor-1_1
- GSM7966547 Css_Z8__inhibitor-2_1
- GSM7966548 Z8-1 Z8
- GSM7966549 Z8-2 Z8
- GSM7966550 Z8-3 Z8
- GSM8008593 EVbrg1
- GSM8008594 Z8brg1
- GSM8008596 Z8foxm1
- GSM8008597 EVK27
- GSM8008598 Z8K27
- GSM8008599 K4me1
- GSM8008600 K14ac
- GSM8012484 foxm1KD
- GSM8012485 Z8KD
- GSE242464 Epigenetic regulation of p63 blocks squamous-to-neuroendocrine transdifferentiation in esophageal development and malignancy 53 samples shares transdifferentiation, neuroendocrine, epigenetic
- GSE291268 Cardiac Radiotherapy-Induced Epigenetic Memory Underlies Electrophysiologic and Metabolic Reprogramming [ATAC-seq] 50 samples shares reprogramming, epigenetic
- GSE325735 Transcriptomic reprogramming screen identifies SRSF1 as a regulator of aging 839 samples shares reprogramming
- GSE156337 Onco-fetal reprogramming of endothelial cells drives immunosuppressive macrophages in Hepatocellular Carcinoma 186 samples shares reprogramming
- GSE99311 Enhancer reprogramming promotes pancreatic cancer progression and metastasis 136 samples shares reprogramming
- GSE201710 Targeted partial reprogramming of age-associated cell states improves markers of health in mouse models of aging 49 samples shares reprogramming
- GSE290486 Matched single-cell chromatin, transcriptome, and surface marker profiling captures in vivo epigenomic reprogramming during basal-to-luminal transition in the mammary gland 37 samples shares reprogramming
- GSE275278 Transplantation-induced reprogramming determines successful hepatocyte engraftment 37 samples shares reprogramming
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.