← BioTransfer GEO Dataset Finder
GEO series

Role of copper in progression of clear cell renal cell carcinoma [RNA-seq]

GSE250028 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2024/10/18 Platform GPL20795
Summary
Copper (Cu) is an essential trace element required for mitochondrial respiration. We show that Cu drives coordinated metabolic remodeling of bioenergy, biosynthesis and redox homeostasis and progression of clear cell renal cell carcinoma (ccRCC). Cu stimulates tumor growth. Late-stage ccRCCs accumulate Cu and allocate it to cytochrome c oxidase stimulating bioenergy production. Cu induces TCA cycle-dependent oxidation of glucose and its utilization for biosynthesis of a glutathione pool that protects against H2O2 generated during mitochondrial respiration, therefore coordinating bioenergy production with redox protection.
Published in
Copper Drives Remodeling of Metabolic State and Progression of Clear Cell Renal Cell Carcinoma
Bischoff ME, Shamsaei B, Yang J et al. · Cancer discovery 2025 · PMID 39476412 · doi:10.1158/2159-8290.CD-24-0187
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE250028_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1051628 and SRA study SRP477631. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 6 more — browse all 6 samples with per-sample file links →

Similar datasets

Search all human RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.