GEO series
Rhabdomyosarcoma transcriptomics upon PAX3-FOXO1 rescue with other fusion proteins
GSE250125
Homo sapiens
Expression profiling by high throughput sequencing
27 samples
2026/03/26
GPL24676
Summary
PAX3-FOXO1 is the commonly identified oncofusion gene found in rhabdomyosarcoma. However, other rare fusions are also seen. Here, we have knocked down PAX3-FOXO1 in a fusion-positive RMS cell line (RH4) with shRNA targeting the breakpoint and rescued cell growth with 7 fusions found in this cancer. RNA sequencing was then used to asess how each fusion alters transcription by comparing the RNA sequencing to a PAX3-FOXO1 knock down cell.
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Paper (PMID 42209514) ↗
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