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PKC inhibition overcomes chemo-resistance in TNBC by restoring Aurora kinase B expression

GSE250221 Homo sapiens Expression profiling by high throughput sequencing 4 samples Submitted 2025/12/31 Platform GPL24676
Summary
Triple negative breast cancer (TNBC) poses a significant challenge due to its high mortality rates, primarily attributed to resistance against chemotherapy regimens containing taxanes like paclitaxel. Overcoming this resistance is imperative for improving patient outcomes. In this context, the study aimed to identify more efficient combinatorial strategies to tackle with paclitaxel resistance in TNBC.
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Direct links to NCBI, no account and no request form: the whole study as GSE250221_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 4 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1052692 and SRA study SRP478086. Searching any of these in the dataset finder brings you back here.

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