Oncohistone H3.3K27M-driven CREB5/ID1 Axis Mediates the Malignant Cell States of Diffuse Intrinsic Pontine Glioma (DIPG) [CUT&Tag]
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 26 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 26 samples: 13 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- An oncohistone-driven H3.3K27M/CREB5/ID1 axis maintains the stemness and malignancy of diffuse intrinsic pontine gliomaNature communications · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE250464_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1054111 and SRA study SRP478711. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 26 samples.
How we read this: 13 replicated groups read from 26 sample titles; they account for 26 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7979468 CREB5_rep1 CREB5
- GSM7979469 CREB5_rep2 CREB5
- GSM7979470 H3K27M_rep1 H3K27M
- GSM7979471 H3K27M_rep2 H3K27M
- GSM7979472 WT_BRG1_rep1 WT_BRG1
- GSM7979473 WT_BRG1_rep2 WT_BRG1
- GSM7979474 CREB5KD_BRG1_rep1 CREB5KD_BRG1
- GSM7979475 CREB5KD_BRG1_rep2 CREB5KD_BRG1
- GSM7979476 WT_H3K9me2_rep1 WT_H3K9me2
- GSM7979477 WT_H3K9me2_rep2 WT_H3K9me2
- GSM7979478 CREB5KD_H3K9me2_rep1 CREB5KD_H3K9me2
- GSM7979479 CREB5KD_H3K9me2_rep2 CREB5KD_H3K9me2
- GSM7979480 WT_H3K27me3_rep1 WT_H3K27me3
- GSM7979481 WT_H3K27me3_rep2 WT_H3K27me3
- GSM7979482 H3K27MKD1_H3K27me3_rep1 H3K27MKD1_H3K27me3
- GSM7979483 H3K27MKD1_H3K27me3_rep2 H3K27MKD1_H3K27me3
- GSM7979484 H3K27MKD2_H3K27me3_rep1 H3K27MKD2_H3K27me3
- GSM7979485 H3K27MKD2_H3K27me3_rep2 H3K27MKD2_H3K27me3
- GSM7979486 PPC_H3K27M_rep1 PPC_H3K27M
- GSM7979487 PPC_H3K27M_rep2 PPC_H3K27M
- GSM7979488 H3WT_H3K27me3_rep1 H3WT_H3K27me3
- GSM7979489 H3WT_H3K27me3_rep2 H3WT_H3K27me3
- GSM7979490 H3K27MOE_H3K27me3_rep1 H3K27MOE_H3K27me3
- GSM7979491 H3K27MOE_H3K27me3_rep2 H3K27MOE_H3K27me3
- GSM7979492 H3K27MOE_H3K27ac_rep1 H3K27MOE_H3K27ac
- GSM7979493 H3K27MOE_H3K27ac_rep2 H3K27MOE_H3K27ac
- GSE269555 Targeting the oncohistone-ASCL1 axis disrupts plasticity and suppresses pediatric gliomas [CUT&RUN] 39 samples shares cut, oncohistone
- GSE327821 Single-molecule, single-cell profiling of linked chromatin states [Single_cell_CoCUT&Tag] 200 samples shares cut
- GSE339365 Genome-wide H3K4me3 profiling of circulating immune cells reveals dynamic epigenetic reprogramming during acute critical COVID-19 120 samples shares cut
- GSE289467 Intraindividual epigenetic heterogeneity underlying phenotypic subtypes of advanced prostate cancer [CUT&Tag] 50 samples shares cut
- GSE303343 A unified network systems approach uncovers a core program underlying T follicular helper cell differentiation [CUT&RUN] 48 samples shares cut
- GSE294275 Transcriptional analysis of direct NSD2 target genes in t(4;14) multiple myeloma reveals H3K36me2-dependent regulation and H3K27me3 antagonism [CUT&TAG] 40 samples shares cut
- GSE287902 BPTF regulstes androgen receptor activity by enhancing chromatin accessibility and stabilizing the AR-FOXA1 interaction [Cut&Run] 40 samples shares cut
- GSE307363 3D epigenomic landscape of human retinal pigment epithelium [CUT&Tag] 40 samples shares cut
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.