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Apigenin inhibits tumor angiogenesis by suppressing microvesicle biogenesis

GSE251817 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2024/07/22 Platform GPL24676
Summary
Apigenin regulates multiple pathways related to microvesicle biogenesis without affecting the expression of small Rho GTPase activator guanine nucleotide exchange factors (GEFs). However, apigenin can primarily targets ARHGEF1 protein, a GEF of the small GTPases, thereby inhibiting the activity of small G proteins such as Cdc42, which is essential in regulating the signaling for the release of microvesicles from tumor cells. Targeting ARHGEF1, apigenin effectively prevents tumor cells from releasing microvesicles. This, in turn, inhibits tumor angiogenesis related to VEGF90K transport on microvesicles, ultimately impeding tumor progression.
Published in
Apigenin inhibits tumor angiogenesis by hindering microvesicle biogenesis via ARHGEF1
Zhang W, Zhuang X, Wu C et al. · Cancer letters 2024 · PMID 38823764 · doi:10.1016/j.canlet.2024.216961
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Also filed as BioProject PRJNA1055490 and SRA study SRP479476. Searching any of these in the dataset finder brings you back here.

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