GEO series
RNA-sequence analysis of human iPSC-derived qHSCs, aHSCs and deactivated HSCs
GSE251824
Homo sapiens
Expression profiling by high throughput sequencing
12 samples
2024/05/01
GPL28038
Summary
Hepatic stellate cells (HSCs) are the major driver of fibrosis by expressing extracellular matrices (ECM). HSCs, in the normal liver, are quiescent and activated by liver injury to become myofibroblasts that proliferate and produce ECM. It has been shown that activated HSCs can be deactivated by removal of liver insults. In order to evaluate the changes of gene expression profiles, we induced quiescent HSCs (qHSCs), activated HSCs (aHSCs) and deactivated HSCs (daHSCs) from human induced pluripotent stem cells and performed RNA-sequence analysis.
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Paper (PMID 38609454) ↗
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