Transcriptomics Profiling of the Non-Small Cell Lung Cancer (NSCLC) Microenvironment Reveals Dual Immune Cell-Type Behaviors
RNA-seq (gene expression) · human · 62 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Topic
- Lung cancerThis series is part of our curated briefing on it.
- Samples
- 62 samples: 51 × Sample vs 10 × SampleTGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Transcriptomics profiling of the non-small cell lung cancer microenvironment across disease stages reveals dual immune cell-type behaviorsFrontiers in immunology · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE251840_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1055533 and SRA study SRP479488. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 61 samples.
How we read this: 2 replicated groups read from 62 sample titles; they account for 61 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7988882 Sample-01 Sample
- GSM7988883 Sample-02 Sample
- GSM7988884 Sample-03 Sample
- GSM7988885 Sample-04 Sample
- GSM7988886 Sample-08 Sample
- GSM7988887 Sample-10 Sample
- GSM7988888 Sample-12 Sample
- GSM7988889 Sample-14 Sample
- GSM7988890 Sample-15 Sample
- GSM7988891 Sample-16 Sample
- GSM7988892 Sample-17 Sample
- GSM7988893 Sample-18 Sample
- GSM7988894 Sample-19 Sample
- GSM7988895 Sample-20 Sample
- GSM7988896 Sample-22 Sample
- GSM7988897 Sample-23 Sample
- GSM7988898 Sample-24 Sample
- GSM7988899 Sample-25 Sample
- GSM7988900 Sample-28 Sample
- GSM7988901 Sample-29 Sample
- GSM7988902 Sample-31 Sample
- GSM7988903 Sample-32 Sample
- GSM7988904 Sample-34 Sample
- GSM7988905 Sample-35 Sample
- GSM7988906 Sample-37 Sample
- GSM7988907 Sample-38 Sample
- GSM7988908 Sample-40 Sample
- GSM7988909 Sample-42 Sample
- GSM7988910 Sample-43 Sample
- GSM7988911 Sample-44 Sample
- GSM7988912 Sample-45 Sample
- GSM7988913 Sample-46 Sample
- GSM7988914 Sample-47 Sample
- GSM7988915 Sample-48 Sample
- GSM7988916 Sample-52 Sample
- GSM7988917 Sample-53 Sample
- GSM7988918 Sample-56A
- GSM7988919 Sample-57 Sample
- GSM7988920 Sample-58 Sample
- GSM7988921 Sample-59 Sample
+ 22 more — browse all 62 samples with per-sample file links →
- GSE127465 Single cell transcriptomics of human and mouse lung cancers reveals conserved myeloid populations across individuals and species 40 samples same disease briefing · shares lung, dual
- GSE241518 High-throughout sequencing of colorectal cancer and non-small cell lung cancer cells treated actived compound YHM18 4 samples same disease briefing · shares non-small, lung
- GSE104244 Bone Marrow Derived Macrophages, NSCLC cell lines, and Kras G12D Lung Tumors Treated with Epigenetic Agents 33 samples same disease briefing · shares nsclc, lung
- GSE114761 Transforming Growth Factor β-Induced Epithelial-to-Mesenchymal Signature Predicts Metastasis-Free Survival in Non-Small Cell Lung Cancer. 42 samples same disease briefing · shares non-small, lung
- GSE117570 Reprogramming of Tumor-infiltrating Immune Cells in Early Stage of NSCLC 8 samples same disease briefing · shares nsclc
- GSE103550 Lung Cancer Cell-Mediated Skeletal Muscle Mitochondrial Dysfunction is Mitigated by 1a,25-Dihydroxyvitamin D3 24 samples same disease briefing · shares lung
- GSE10072 Gene expression signature of cigarette smoking and its role in lung adenocarcinoma development and survival 107 samples same disease briefing · shares lung
- GSE17958 Affymetrix SNP array data for 47 lung squamous cell carcinoma and 40 esophageal squamous cell carcinoma samples. 87 samples same disease briefing · shares lung
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.