GEO series
NR4A2 and NR4A3 selectively modulate elements of the monocyte response to buffered hypercapnia
GSE251925
Homo sapiens
Expression profiling by high throughput sequencing
36 samples
2024/03/20
GPL20301
Summary
In wild type, NR4A2-deficient, and NR4A3-deficient monocytes we used RNA-sequencing to investigate the effect of 4hrs of exposure to buffered hypercapnia (10% CO2) compared to normocapnia (5% CO2) with and without the pro-inflammatory stimulus LPS (2.5ug/ml) for the final 2hrs. Buffered hypercapnia causes transcriptional changes associated with altered metabolic function in both the basal and stimulated states.
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Paper (PMID 38474099) ↗
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