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The profiling of methylation and acetylation modification of histone H3 in Intrahepatic cholangiocarcinoma cells

GSE252098 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 6 samples Submitted 2025/01/20 Platform GPL11154
Summary
Abnormal distribution of histone modifications has been confirmed to influence the development and progression of neoplastic diseases. Methylation modifications of histone H3 include H3K9me3, H3K27me3 and H3K4me3. Acetylation modifications of histone H3 include H3K9ac and H3K27ac. Among these modifications in the promoter region, H3K9me3 and H3K27me3 serve as inhibiting factors for transcription, while H3K4me3, H3K9ac and H3K27ac are important promoting factors for transcription. To make sure the distribution of these histone modifications in intrahepatic cholangiocarcinoma (ICCA) cells, CUT & Tag was performed. We found that these modifications were located in the promoter or non-promoter regions (e.g., intergenic, exon and intron regions) of key tumor-associated genes, indicating the potential role of chromatin remodeling complexes in ICCA diagnosis and treatment.
Published in
Unveiling the role of HP1α-HDAC1-STAT1 axis as a therapeutic target for HP1α-positive intrahepatic cholangiocarcinoma
Xiong F, Wang D, Xiong W et al. · Journal of experimental & clinical cancer research : CR 2024 · PMID 38812060 · doi:10.1186/s13046-024-03070-3
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Also filed as BioProject PRJNA1057797 and SRA study SRP480285. Searching any of these in the dataset finder brings you back here.

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