The effect of STING knockout on gene expression in DMXAA-induced BMDMs and BMDCs
RNA-seq (gene expression) · mouse · 24 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 24 samples: 8 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Intestinal epithelial damage-derived mtDNA activates STING-IL12 axis in dendritic cells to promote colitisTheranostics · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE252101_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1057802 and SRA study SRP480282. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 24 samples.
How we read this: 8 replicated groups read from 24 sample titles; they account for 24 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7993639 M_WT_CT1 M_WT_CT
- GSM7993640 M_WT_DX1 M_WT_DX
- GSM7993641 M_CRE_CT1 M_CRE_CT
- GSM7993642 M_CRE_DX1 M_CRE_DX
- GSM7993643 M_WT_CT2 M_WT_CT
- GSM7993644 M_WT_DX2 M_WT_DX
- GSM7993645 M_CRE_CT2 M_CRE_CT
- GSM7993646 M_CRE_DX2 M_CRE_DX
- GSM7993647 M_WT_CT3 M_WT_CT
- GSM7993648 M_WT_DX3 M_WT_DX
- GSM7993649 M_CRE_CT3 M_CRE_CT
- GSM7993650 M_CRE_DX3 M_CRE_DX
- GSM7993651 C_WT_CT1 C_WT_CT
- GSM7993652 C_WT_DX1 C_WT_DX
- GSM7993653 C_CRE_CT1 C_CRE_CT
- GSM7993654 C_CRE_DX1 C_CRE_DX
- GSM7993655 C_WT_CT2 C_WT_CT
- GSM7993656 C_WT_DX2 C_WT_DX
- GSM7993657 C_CRE_CT2 C_CRE_CT
- GSM7993658 C_CRE_DX2 C_CRE_DX
- GSM7993659 C_WT_CT3 C_WT_CT
- GSM7993660 C_WT_DX3 C_WT_DX
- GSM7993661 C_CRE_CT3 C_CRE_CT
- GSM7993662 C_CRE_DX3 C_CRE_DX
- GSE284373 The effect of STING knockout on gene expression in cholestatic mice 20 samples shares sting, knockout
- GSE240884 The gene expression profiling of 3'2'-cCAMP signaling and 2'3'-cGAMP signaling in the BMDMs of WT and STING deficienc mice 24 samples shares sting, bmdms
- GSE290224 Intermittent Fasting Reprograms Chromatin Accessibility to Modulate Gene Expression in Brain and Muscle 96 samples shares sting
- GSE271744 Bulk RNAseq of mononucleated cells isolated from resting and regenerating adult and aged skeletal mouse muscle 107 samples shares sting
- GSE331176 Phagosome-mediated activation of STING by purine and pyrimidine-based bacterial cyclic dinucleotides 380 samples shares sting
- GSE237084 Non-CG DNA methylation and MeCP2 stabilize repeated tuning of long genes that distinguish closely related neuron types [RNA-seq] 38 samples shares sting
- GSE296709 Effect of depletion of Endothelial Cell STING in response to pressure overload induced heart failure 15 samples shares sting
- GSE241587 Pervasive nuclear envelope ruptures precede ECM signaling and disease onset without activating cGAS-STING in Lamin cardiomyopathy mice [sci-RNA-seq] 96 samples shares sting
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.