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Castrate Resistant Prostate Cancer Response to Taxane is Determined by an HNF1-dependent Apoptosis Resistance Circuit (RNA-Seq)

GSE252216 Homo sapiens Expression profiling by high throughput sequencing 8 samples Submitted 2024/04/01 Platform GPL18573
Summary
Metastatic castrate-resistant prostate cancer (mCRPC) is a genetically and phenotypically heterogeneous cancer where advancements are needed in biomarker discovery and targeted therapy. A critical and often effective component of treatment includes taxanes. We performed one of the first high throughput screens across a cohort of 30 diverse patient-derived CRPC organoids to a library of 78 drugs. Combining quantitative response measures with transcriptomic analyses demonstrated that HNF1 Homeobox A (HNF1A) drives a transcriptional program of taxane resistance, dependent upon cellular inhibitor of apoptosis protein 2 (cIAP2). Monotherapy with cIAP2 inhibitor LCL161 was sufficient to treat HNF1A+ models of mCRPC previously resistant to docetaxel.
Published in
Castrate-resistant prostate cancer response to taxane is determined by an HNF1-dependent apoptosis resistance circuit
Senatorov IS, Bowman J, Jansson KH et al. · Cell reports. Medicine 2024 · PMID 39657662 · doi:10.1016/j.xcrm.2024.101868
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Also filed as BioProject PRJNA1058598. Searching any of these in the dataset finder brings you back here.

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