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Effect of treatment by BAY1217389 for 48 hr on H1944

GSE252340 Homo sapiens Expression profiling by high throughput sequencing 4 samples Submitted 2024/05/08 Platform GPL24676
Summary
We reported that MPS-1 inhibitors activate cGAS-STING pathway in tumor cells by forming micronuclei and inducing cytokine secretion such as type I interferon, CCL5, and CXCL10, thereby promoting immune cell migration and inducing tumor cell shrinkage. In the present study, we performed RNA -seq to search for negative regulators of STING pathway by forcibly activating it in H1944 cells with MPS-1 inhibitors, BAY1217389 and found that the administration of BAY1217389 for 48-hour treatment increased downstream factors of STING pathway and genes involved in antigen presentation, while we found elevation of negative regulators such as TREX1.
Published in
TREX1 Inactivation Unleashes Cancer Cell STING-Interferon Signaling and Promotes Antitumor Immunity
Tani T, Mathsyaraja H, Campisi M et al. · Cancer discovery 2024 · PMID 38227896 · doi:10.1158/2159-8290.CD-23-0700
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Also filed as BioProject PRJNA1060253 and SRA study SRP480996. Searching any of these in the dataset finder brings you back here.

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