U1 snRNP regulates alternative promoter activity by inhibiting premature polyadenylation
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 47 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 47 samples: 16 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE252392_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1060322 and SRA study SRP552503. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 47 samples.
How we read this: 16 replicated groups read from 47 sample titles; they account for 47 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8000674 RNA-seq_Ctrl1 RNA-seq_Ctrl
- GSM8000675 RNA-seq_Ctrl2 RNA-seq_Ctrl
- GSM8000676 RNA-seq_U1AMO1 RNA-seq_U1AMO
- GSM8000677 RNA-seq_U1AMO2 RNA-seq_U1AMO
- GSM8000678 RNA-seq_U1AMO3 RNA-seq_U1AMO
- GSM8000683 ATAC-seq_Ctrl1 ATAC-seq_Ctrl
- GSM8000684 ATAC-seq_Ctrl2 ATAC-seq_Ctrl
- GSM8000685 ATAC-seq_Ctrl3 ATAC-seq_Ctrl
- GSM8000686 ATAC-seq_U1AMO1 ATAC-seq_U1AMO
- GSM8000687 ATAC-seq_U1AMO2 ATAC-seq_U1AMO
- GSM8000688 ATAC-seq_U1AMO3 ATAC-seq_U1AMO
- GSM8000694 CUT&RUN_H3K4me3_Ctrl1 CUT&RUN_H3K4me3_Ctrl
- GSM8000695 CUT&RUN_H3K4me3_Ctrl2 CUT&RUN_H3K4me3_Ctrl
- GSM8000696 CUT&RUN_H3K4me3_Ctrl3 CUT&RUN_H3K4me3_Ctrl
- GSM8000697 CUT&RUN_H3K4me3_U1AMO1 CUT&RUN_H3K4me3_U1AMO
- GSM8000698 CUT&RUN_H3K4me3_U1AMO2 CUT&RUN_H3K4me3_U1AMO
- GSM8000699 CUT&RUN_H3K4me3_U1AMO3 CUT&RUN_H3K4me3_U1AMO
- GSM8000700 CUT&RUN_RNAPII_Ctrl1 CUT&RUN_RNAPII_Ctrl
- GSM8000701 CUT&RUN_RNAPII_Ctrl2 CUT&RUN_RNAPII_Ctrl
- GSM8000702 CUT&RUN_RNAPII_Ctrl3 CUT&RUN_RNAPII_Ctrl
- GSM8000703 CUT&RUN_RNAPII_U1AMO1 CUT&RUN_RNAPII_U1AMO
- GSM8000704 CUT&RUN_RNAPII_U1AMO2 CUT&RUN_RNAPII_U1AMO
- GSM8000705 CUT&RUN_RNAPII_U1AMO3 CUT&RUN_RNAPII_U1AMO
- GSM8000706 CUT&RUN_Ser2P_Ctrl1 CUT&RUN_Ser2P_Ctrl
- GSM8000707 CUT&RUN_Ser2P_Ctrl2 CUT&RUN_Ser2P_Ctrl
- GSM8000708 CUT&RUN_Ser2P_Ctrl3 CUT&RUN_Ser2P_Ctrl
- GSM8000709 CUT&RUN_Ser2P_U1AMO1 CUT&RUN_Ser2P_U1AMO
- GSM8000710 CUT&RUN_Ser2P_U1AMO2 CUT&RUN_Ser2P_U1AMO
- GSM8000711 CUT&RUN_Ser2P_U1AMO3 CUT&RUN_Ser2P_U1AMO
- GSM8000712 CUT&RUN_Ser5P_Ctrl1 CUT&RUN_Ser5P_Ctrl
- GSM8000713 CUT&RUN_Ser5P_Ctrl2 CUT&RUN_Ser5P_Ctrl
- GSM8000714 CUT&RUN_Ser5P_Ctrl3 CUT&RUN_Ser5P_Ctrl
- GSM8000715 CUT&RUN_Ser5P_U1AMO1 CUT&RUN_Ser5P_U1AMO
- GSM8000716 CUT&RUN_Ser5P_U1AMO2 CUT&RUN_Ser5P_U1AMO
- GSM8000717 CUT&RUN_Ser5P_U1AMO3 CUT&RUN_Ser5P_U1AMO
- GSM8690468 PRO-seq_Ctrl1 PRO-seq_Ctrl
- GSM8690469 PRO-seq_Ctrl2 PRO-seq_Ctrl
- GSM8690470 PRO-seq_Ctrl3 PRO-seq_Ctrl
- GSM8690471 PRO-seq_U1ASO1 PRO-seq_U1ASO
- GSM8690472 PRO-seq_U1ASO2 PRO-seq_U1ASO
+ 7 more — browse all 47 samples with per-sample file links →
- GSE252391 U1 snRNP regulates alternative promoter activity by inhibiting premature polyadenylation [CUT&RUN] 24 samples shares polyadenylation, alternative, inhibiting, premature, promoter, activity, snrnp
- GSE313109 HIV-1 Infection Regulates Gene Expression by Altering Alternative Polyadenylation Through CPSF6 and CPSF5 Delocalization 28 samples shares polyadenylation, alternative
- GSE269600 Multiplexed single-cell characterization of alternative polyadenylation regulators 52 samples shares polyadenylation, alternative
- GSE304550 ALS-Associated TDP-43 Dysfunction Compromises UPF1-Dependent mRNA Metabolism Pathways Including Alternative Polyadenylation and 3’UTR Length 16 samples shares polyadenylation, alternative
- GSE291390 Single-cell landscape and regulation of alternative polyadenylation in the brain 15 samples shares polyadenylation, alternative
- GSE210746 Characterization of 3′UTRCES-mediated alternative polyadenylation (APA) engineering in prostate cancer and 293FT cells 15 samples shares polyadenylation, alternative
- GSE269596 Multiplexed single-cell characterization of alternative polyadenylation regulators (scRNA-Seq) 12 samples shares polyadenylation, alternative
- GSE336445 Androgen Receptor-Driven RASSF3 Upregulation Promotes CKD Progression by Inhibiting Gαs/Gq Activity to Mediate Metabolic Reprogramming [DT] 8 samples shares inhibiting, activity
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.