Targeting the tissue factor coagulation initiation complex prevents antiphospholipid antibody development.
RNA-seq (gene expression) · mouse · 10 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 10 samples: 5 × Saline vs 5 × rNAPC2Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Targeting the tissue factor coagulation initiation complex prevents antiphospholipid antibody developmentBlood · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE252397_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1060333 and SRA study SRP481020. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 10 samples.
How we read this: 2 replicated groups read from 10 sample titles; they account for 10 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8000764 Saline replicate 1 Saline
- GSM8000765 Saline replicate 2 Saline
- GSM8000766 Saline replicate 3 Saline
- GSM8000767 Saline replicate 4 Saline
- GSM8000768 Saline replicate 5 Saline
- GSM8000769 rNAPC2 replicate 1 rNAPC2
- GSM8000770 rNAPC2 replicate 2 rNAPC2
- GSM8000771 rNAPC2 replicate 3 rNAPC2
- GSM8000772 rNAPC2 replicate 4 rNAPC2
- GSM8000773 rNAPC2 replicate 5 rNAPC2
- GSE286046 Asymmetric Histone Inheritance Regulates Differential Transcription Re-initiation and Cell Fate Decisions in Mouse Olfactory Horizontal Basal Cells 96 samples shares initiation, factor
- GSE313351 Intestinal BMP SMADs impart the mid-villus pattern via direct targeting of villus zonation genes and by controlling a transcription factor hierarchy [RNA-seq] 26 samples shares targeting, factor
- GSE330229 Accelerated RNA polymerase II elongation drives endothelial transition and plaque vulnerability: pharmacological targeting of the super elongation complex [RNA-seq] 24 samples shares targeting, complex
- GSE330629 A humanized monoclonal antibody targeting human ENPP1, an ectonucleotidase expressed in the diseased human kidney, enhances tubular proliferation and kidney repair and is safe in non-human primates 24 samples shares targeting, antibody
- GSE264673 EPOP Restricts PRC2.1 Targeting to Chromatin by Directly Modulating Enzyme Complex Dimerization (RNA-Seq) 12 samples shares targeting, complex
- GSE214518 Myeloid cell coagulation factor Xa-protease activated receptor 2 signaling inhibition expands progenitor exhausted T-cells in the tumor microenvironment 12 samples shares coagulation, factor
- GSE284500 Transcriptional profiling of hippocampus from a zQ175 KI mouse model of Huntington's disease treated with either HTT-10150 siRNA targeting full-length HTT or combination of HTT-634 and HTT-486 siRNAs targeting HTT1a 192 samples shares targeting
- GSE284497 Transcriptional profiling of striatum from a zQ175 KI mouse model of Huntington's disease treated with HTT-10150 siRNA targeting full-length Htt 143 samples shares targeting
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.