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Genetic background and aging-driven neuroimmune and disc changes underscore herniation susceptibility and pain-associated behaviors in SM/J mice

GSE252474 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2025/04/30 Platform GPL19057
Summary
SM/J mice experience spontaneous age-associated intervertebral disc herniations, with molecular analyses indicating a dysregulated immune system may contribute to this disc pathology. To investigate this, we analyzed the circulating immune cells of these mice during aging, in relation to BL/6 mice, which do not experience disc herniation.
Published in
Genetics- and age-driven neuroimmune and disc changes underscore herniation susceptibility and pain-associated behaviors in SM/J mice
Novais EJ, Ottone OK, Brown EV et al. · Science advances 2025 · PMID 40267183 · doi:10.1126/sciadv.ado6847
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Also filed as BioProject PRJNA1060705 and SRA study SRP481168. Searching any of these in the dataset finder brings you back here.

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