Decoding the YAP/TAZ–PPARγ Regulatory Axis in Adipocyte Differentiation and Dedifferentiation
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 70 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 70 samples: 56 distinct titles, 14 of them repeatedGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- YAP/TAZ-VGLL3 governs adipocyte fate via epigenetic reprogramming of PPARγ and its target enhancersScience advances · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE252504_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1060795 and SRA study SRP532732. Searching any of these in the dataset finder brings you back here.
How we read this: Read from 70 sample titles: 56 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7912149 D0 biol rep1 [CR1]
- GSM7912150 D0 biol rep2 [CR2]
- GSM7912151 D1 biol rep1 [CR3]
- GSM7912152 D1 biol rep2 [CR4]
- GSM7912153 D6 biol rep1 [CR21]
- GSM7912154 D6 biol rep2 [CR22]
- GSM7912155 D6TAZ biol rep1 [CR23]
- GSM7912156 D6TAZ biol rep2 [CR24]
- GSM8002279 D0 biol rep1
- GSM8002280 D0 biol rep2
- GSM8002281 D1 biol rep1
- GSM8002282 D1 biol rep2
- GSM8002283 D6 biol rep1
- GSM8002284 D6 biol rep2
- GSM8002285 D6TAZ biol rep1
- GSM8002286 D6TAZ biol rep2
- GSM8516300 3FC7_Control_Ac1
- GSM8516301 3FC8_Control_Ac2
- GSM8516302 3FC9_LAKO_Ac1
- GSM8516303 3FC10_LAKO_Ac2
- GSM8516304 D0_PRg1
- GSM8516305 D0_PRg2
- GSM8516306 D6_PPARg1
- GSM8516307 D6_PPARg2
- GSM8516308 D6TAZ_PPARg1
- GSM8516309 D6TAZ_PPARg2
- GSM8516310 D0_Kac1
- GSM8516311 D0_Kac2
- GSM8516312 D6_Kac1
- GSM8516313 D6_Kac2
- GSM8516314 D6TAZ_Kac1
- GSM8516315 D6TAZ_Kac2
- GSM8516316 3CC1_Con_Kac1
- GSM8516317 3CC2_Con_Kac2
- GSM8516318 3CC3_TAZ2SA_Kac1
- GSM8516319 3CC4_TAZ2SA_Kac2
- GSM8516322 3CC7_dWW_S51A_Kac1
- GSM8516323 3CC8_dWW_S51A_Kac2
- GSM8516324 4CC6_D6VGLL3_Kac1
- GSM8516325 4CC22_ConD6_Kac1
+ 30 more — browse all 70 samples with per-sample file links →
- GSE277188 Decoding the YAP/TAZ–PPARγ Regulatory Axis in Adipocyte Differentiation and Dedifferentiation [ChIP-seq] 46 samples shares ppar, yap, taz, dedifferentiation, regulatory, adipocyte, decoding, axis
- GSE301501 Extracellular matrix reprogramming by the YAP/TAZ/TGF-ß2 axis drives immune exclusion in cholangiocarcinoma models 45 samples shares yap, taz, axis
- GSE301496 Transient YAP/TAZ inhibition exposes therapeutic vulnerabilities in advanced cancers [CUT&Run] 20 samples shares yap, taz
- GSE287588 Yap/Taz function as new mediators of FGF signaling in neural crest-derived cranial suture mesenchymal cells [RNA-seq] 18 samples shares yap, taz
- GSE265949 Effect of endothelial YAP/TAZ on neuroinflammation and outcome after ischemic stroke in mice 16 samples shares yap, taz
- GSE327565 Sustained Yap/Taz activation promotes aberrant alveolar epithelial cell differentiation and drives persistent fibrotic remodeling 14 samples shares yap, taz
- GSE301500 Transient YAP/TAZ inhibition exposes therapeutic vulnerabilities in advanced cancers [ATAC-seq] 11 samples shares yap, taz
- GSE293205 Integrated ERK-PKA-YAP/TAZ-SHH Signaling Orchestrates Cortical Radial Glia Identity and Lineage Diversification 11 samples shares yap, taz
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.