GEO series
Microglia-astrocyte crosstalk regulates synapse remodeling via Wnt signaling
GSE252628
Mus musculus
Expression profiling by high throughput sequencing
56 samples
2025/08/07
GPL24247
Summary
Unilateral whisker lesioning at age P4 leads to removal of thalamocortical synapses in layer IV of the barrel cortex over the course of the next 6 days. Synapse removal is mediated by microglia and induced by CX3CL1-CX3CR1 signaling between neurons and microglia. Downstream of CX3CL1-CX3CR1 activation, microglia induce astrocyte morphological changes. To identify molecular crosstalk between astrocytes and microglia, we performed translating ribosome affinty purification followed by RNA sequencing (TRAP-Seq).
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Paper (PMID 40934914) ↗
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