Microglia-astrocyte crosstalk regulates synapse remodeling via Wnt signaling
RNA-seq (gene expression) · mouse · 56 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 56 samples: 6 conditions, mostly with about 9 replicates eachGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Microglia-astrocyte crosstalk regulates synapse remodeling via Wnt signalingCell · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE252628_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1061535 and SRA study SRP482150. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 36 samples.
How we read this: 6 replicated groups read from 56 sample titles; they account for 36 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8004143 Control P5 barrel cortex astrocytes 1 Control P5 barrel corte…
- GSM8004144 Deprived P5 barrel cortex astrocytes 1 Deprived P5 barrel cort…
- GSM8004145 Control P5 barrel cortex astrocytes 2 Control P5 barrel corte…
- GSM8004146 Deprived P5 barrel cortex astrocytes 2 Deprived P5 barrel cort…
- GSM8004147 Control P5 barrel cortex astrocytes 3 Control P5 barrel corte…
- GSM8004148 Deprived P5 barrel cortex astrocytes 3 Deprived P5 barrel cort…
- GSM8004149 Control P5 barrel cortex astrocytes 4 Control P5 barrel corte…
- GSM8004150 Deprived P5 barrel cortex astrocytes 4 Deprived P5 barrel cort…
- GSM8004151 Control P5 barrel cortex astrocytes 5 Control P5 barrel corte…
- GSM8004152 Deprived P5 barrel cortex astrocytes 5 Deprived P5 barrel cort…
- GSM8004153 Control P5 barrel cortex 1 Control P5 barrel cortex
- GSM8004154 Deprived P5 barrel cortex 1 Deprived P5 barrel cort…
- GSM8004155 Control P5 barrel cortex 2 Control P5 barrel cortex
- GSM8004156 Deprived P5 barrel cortex 2 Deprived P5 barrel cort…
- GSM8004157 Control P5 barrel cortex 3 Control P5 barrel cortex
- GSM8004158 Deprived P5 barrel cortex 3 Deprived P5 barrel cort…
- GSM8004159 Control P5 barrel cortex 4 Control P5 barrel cortex
- GSM8004160 Deprived P5 barrel cortex 4 Deprived P5 barrel cort…
- GSM8004161 Control P5 barrel cortex 5 Control P5 barrel cortex
- GSM8004162 Deprived P5 barrel cortex 5 Deprived P5 barrel cort…
- GSM8004163 Deprived P5 barrel cortex microglia 1 Deprived P5 barrel cort…
- GSM8004164 Control P5 barrel cortex microglia 1 Control P5 barrel corte…
- GSM8004165 Deprived P5 barrel cortex microglia 2 Deprived P5 barrel cort…
- GSM8004166 Control P5 barrel cortex microglia 2 Control P5 barrel corte…
- GSM8004167 Deprived P5 barrel cortex microglia 3 Deprived P5 barrel cort…
- GSM8004168 Deprived P5 barrel cortex microglia 4 Deprived P5 barrel cort…
- GSM8004169 Control P5 barrel cortex microglia 3 Control P5 barrel corte…
- GSM8004170 Control P5 barrel cortex microglia 4 Control P5 barrel corte…
- GSM8004171 Deprived P5 barrel cortex 7 Deprived P5 barrel cort…
- GSM8004172 Control P5 barrel cortex 7 Control P5 barrel cortex
- GSM8004173 Deprived P5 barrel cortex 8 Deprived P5 barrel cort…
- GSM8004174 Control P5 barrel cortex 8 Control P5 barrel cortex
- GSM8004175 Deprived P5 barrel cortex 9 Deprived P5 barrel cort…
- GSM8004176 Deprived P5 barrel cortex 10 Deprived P5 barrel cort…
- GSM8004177 Control P5 barrel cortex 9 Control P5 barrel cortex
- GSM8004178 Control P5 barrel cortex 10 Control P5 barrel cortex
- GSM8965272 Deprived P5 Cx3cr1-KO barrel cortex microglia [7L]
- GSM8965273 Control P5 Cx3cr1-KO barrel cortex microglia [7R]
- GSM8965274 Deprived P5 Cx3cr1-KO barrel cortex microglia [12L]
- GSM8965275 Control P5 Cx3cr1-KO barrel cortex microglia [12R]
+ 16 more — browse all 56 samples with per-sample file links →
- GSE273494 Pattern separation memory requires Cerebellin 4-Neogenin 1 signaling at dentate gyrus synapses 36 samples shares synapse
- GSE339586 Extensive Crosstalk between BMP and Notch Signaling Pathways in Activated Adult Muscle Stem Cells [RNA-seq III] 24 samples shares crosstalk
- GSE304862 Semaglutide and exercise synergy in obesity: preserving muscle mass and uncovering organ crosstalk 209 samples shares crosstalk
- GSE274492 The remodeling of bivalent chromatin is essential for mouse peri-implantation embryogenesis [Valid RNA-Seq] 200 samples shares remodeling
- GSE259380 TG6050, an oncolytic vaccinia virus encoding interleukin-12 and anti-CTLA-4 antibody induces tumor regression through profound tumor microenvironment remodeling and strong antitumor adaptive immune response [RNA-seq] 149 samples shares remodeling
- GSE300757 Efferocytosis induces proangiogenic function and chromatin remodeling in tumor-associated macrophages 127 samples shares remodeling
- GSE276784 Inflammation perturbs hematopoiesis by remodeling specific compartments of the bone marrow niche 89 samples shares remodeling
- GSE239602 Single-cell and spatial transcriptomics uncovers the role of senescent vascular cells in pathological arterial remodeling during murine atherosclerosis 82 samples shares remodeling
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.