← BioTransfer GEO Dataset Finder
GEO series

Effect of intracellular acidification on senescence-related transcriptomic changes

GSE252672 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2024/04/28 Platform GPL24247
Summary
Several remodeling of intracellular environments has been identified in senescent cells, including enlargement of cell / nuclear size and intracellular acidification. Although these alterations of intracellular environments were reported to be involved in unique characteristics of senescent cells, the contribution of intracellular acidification to senescence-associated cellular phenotypes is poorly understood. Here, we identified that upregulation of TXNIP and its paralog ARRDC4 as a hallmark of intracellular acidification in addition to KGA-type GLS1. These genes were also upregulated in response to senescence-associated intracellular acidification. Neutralization of the intracellular acidic environment ameliorated not only senescence-related upregulation of TXNIP, ARRDC4, and KGA, but also inflammation-related genes, possibly through suppression of glycolysis. Taken toghether, our data implied that the contribution of intracellular pH to senescence-associated cellular features, such as SASP.
Published in
Intracellular acidification and glycolysis modulate inflammatory pathway in senescent cells
Kawakami S, Johmura Y, Nakanishi M · Journal of biochemistry 2024 · PMID 38564227 · doi:10.1093/jb/mvae032
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE252672_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 8 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1061782 and SRA study SRP482250. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 8 more — browse all 8 samples with per-sample file links →

Similar datasets

Search all mouse RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.