Gene expression profiles of complete hydatidiform moles and XBP1-overexpressing cell lines associated with progression to gestational trophoblastic tumors
RNA-seq (gene expression) · human · 25 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 25 samples: 17 distinct titles, 4 of them repeatedGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Elucidation of the role of XBP1 in the progression of complete hydatidiform mole to invasive mole through RNA-seqGynecologic oncology · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE252907_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1063206 and SRA study SRP482890. Searching any of these in the dataset finder brings you back here.
How we read this: Read from 25 sample titles: 17 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8010105 Hmol1-2C_Ctrl_rep1
- GSM8010106 Hmol1-2C_Ctrl_rep2
- GSM8010107 Hmol1-2C_Ctrl_rep3
- GSM8010108 Hmol1-2C_XBP1-OE_rep1
- GSM8010109 Hmol1-2C_XBP1-OE_rep2
- GSM8010110 Hmol1-2C_XBP1-OE_rep3
- GSM8010111 Hmol1-3B_Ctrl_rep1
- GSM8010112 Hmol1-3B_Ctrl_rep2
- GSM8010113 Hmol1-3B_Ctrl_rep3
- GSM8010114 Hmol1-3B_XBP1-OE_rep1
- GSM8010115 Hmol1-3B_XBP1-OE_rep2
- GSM8010116 Hmol1-3B_XBP1-OE_rep3
- GSM8010117 CHM1, control
- GSM8010118 CHM2, control
- GSM8010119 CHM3, control
- GSM8010120 CHM4, control
- GSM8010121 CHM5, control
- GSM8010122 CHM6, control
- GSM8010123 CHM7, control
- GSM8010124 CHM8, low-risk GTN
- GSM8010125 CHM9, low-risk GTN
- GSM8010126 CHM10, low-risk GTN
- GSM8010127 CHM11, low-risk GTN
- GSM8010128 CHM12, low-risk GTN
- GSM8010129 CHM13, low-risk GTN
- GSE252906 The gene expression profiles of complete hydatidiform mole which developed post molar gestational trophoblast neoplasia 13 samples shares hydatidiform, gestational, profiles, complete
- GSE239576 Comparison of Renal Transcriptome Profiles in Patients with Active Lupus Nephritis Reveals Possible New Mechanisms of Disease Progression 21 samples shares progression, profiles
- GSE274680 Inflammation and lymphocyte activation during longitudinal progression to rheumatoid arthritis in at-risk individuals 243 samples shares progression
- GSE263786 Epigenetic heterogeneity hotspots in human liver disease progression [RNA-seq] 243 samples shares progression
- GSE268599 Astrocyte transcriptomic changes along the spatiotemporal progression of Alzheimer’s disease 146 samples shares progression
- GSE328391 Airway immune signatures of protection and disease progression in recent human tuberculosis household contacts [bulk RNA-seq] 125 samples shares progression
- GSE279972 Foamy microglia link oxylipins to disease progression in multiple sclerosis 109 samples shares progression
- GSE275870 Expression profiling of primary and metastatic oral squamous cell carcinoma identifies progression-associated transcriptome changes and therapeutic vulnerabilities 108 samples shares progression
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.