Toggling of BRD4 functions is triggered through its phosphorylation by JNK.
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 52 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 52 samples: 10 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Phosphorylation by JNK switches BRD4 functionsMolecular cell · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE252982_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1063366 and SRA study SRP516310. Searching any of these in the dataset finder brings you back here.
Supports a case/control comparison: 8 samples read as cases, 17 as controls.
How we read this: 10 replicated groups read from 52 sample titles; they account for 30 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8011817 Control empty vector transfected cells, biol rep1 Control empty vector tr…
- GSM8011818 Control empty vector transfected cells, biol rep2 Control empty vector tr…
- GSM8011819 Control empty vector transfected cells, biol rep3 Control empty vector tr…
- GSM8011820 WT BRD4 transfected cells, biol rep 1 WT BRD4 transfected cel…
- GSM8011821 WT BRD4 transfected cells, biol rep 2 WT BRD4 transfected cel…
- GSM8011822 WT BRD4 transfected cells, biol rep 3 WT BRD4 transfected cel…
- GSM8011823 3A-BRD4 transfected cells, biol rep 1 3A-BRD4 transfected cel…
- GSM8011824 3A-BRD4 transfected cells, biol rep 2 3A-BRD4 transfected cel…
- GSM8011825 3A-BRD4 transfected cells, biol rep 3 3A-BRD4 transfected cel…
- GSM8011826 Control empty vector transfected cells, Anisomycin treated ,biol rep1 Control empty vector tr…
- GSM8011827 Control empty vector transfected cells, Anisomycin treated ,biol rep2 Control empty vector tr…
- GSM8011828 Control empty vector transfected cells, Anisomycin treated ,biol rep3 Control empty vector tr…
- GSM8011829 WT BRD4 transfected cells, Anisomycin treated ,biol rep1 WT BRD4 transfected cel…
- GSM8011830 WT BRD4 transfected cells, Anisomycin treated ,biol rep2 WT BRD4 transfected cel…
- GSM8011831 WT BRD4 transfected cells, Anisomycin treated ,biol rep3 WT BRD4 transfected cel…
- GSM8011832 3A-BRD4 transfected cells,anisomycin treated, biol rep 1 3A-BRD4 transfected cel…
- GSM8011833 3A-BRD4 transfected cells,anisomycin treated, biol rep 2 3A-BRD4 transfected cel…
- GSM8011834 3A-BRD4 transfected cells,anisomycin treated, biol rep 3 3A-BRD4 transfected cel…
- GSM8011835 Control empty vector transfected cells, biol rep1, ChIP
- GSM8011836 Control empty vector transfected cells, biol rep2, ChIP
- GSM8011837 WT BRD4 transfected cells, biol rep 1, ChIP
- GSM8011838 WT BRD4 transfected cells, biol rep 2, ChIP
- GSM8011839 3A-BRD4 transfected cells, biol rep 1, ChIP
- GSM8011840 3A-BRD4 transfected cells, biol rep 2, ChIP
- GSM8011841 Control empty vector transfected cells, Anisomycin treated ,biol rep1, ChIP
- GSM8011842 Control empty vector transfected cells, Anisomycin treated ,biol rep2, ChIP
- GSM8011843 WT BRD4 transfected cells, Anisomycin treated ,biol rep1, ChIP
- GSM8011844 WT BRD4 transfected cells, Anisomycin treated ,biol rep2, ChIP
- GSM8011845 3A-BRD4 transfected cells,anisomycin treated, biol rep 1, ChIP
- GSM8011846 Control empty vector transfected cells, biol rep1, input
- GSM8011847 Control empty vector transfected cells, biol rep2, input
- GSM8011848 WT BRD4 transfected cells, biol rep 1, input
- GSM8011849 WT BRD4 transfected cells, biol rep 2, input
- GSM8011850 3A-BRD4 transfected cells, biol rep 1, input
- GSM8011851 3A-BRD4 transfected cells, biol rep 2, input
- GSM8011852 Control empty vector transfected cells, Anisomycin treated ,biol rep1, input
- GSM8011853 Control empty vector transfected cells, Anisomycin treated ,biol rep2, input
- GSM8011854 WT BRD4 transfected cells, Anisomycin treated ,biol rep1, input
- GSM8011855 WT BRD4 transfected cells, Anisomycin treated ,biol rep2, input
- GSM8011856 3A-BRD4 transfected cells,anisomycin treated, biol rep 1, input
+ 12 more — browse all 52 samples with per-sample file links →
- GSE272018 BRD4770 functions as a novel ferroptosis inhibitor to protect against aortic dissection 15 samples shares brd4, functions
- GSE252349 H3S10-phosphorylation spreading in mitosis stably preserves 3D chromatin structure and functions 27 samples shares phosphorylation, functions
- GSE308299 JNK knockdown enhances CAR-T cell cytotoxicity through NFATc1 in preclinical models of ovarian cancer 12 samples shares jnk
- GSE298022 JNK activation dynamics drive distinct gene expression patterns over time mediated by mRNA stability 45 samples shares jnk
- GSE255617 Development of novel Hepatocellular Carcinoma drugs, JNK-IN-5A derivatives simultaneously induce Apoptosis and Necrosis 40 samples shares jnk
- GSE282031 BRD4 O-GlcNAcylation attenuates phase separation to regulate transcription 38 samples shares brd4
- GSE289411 JNK pathway suppression drives resistance to combination endocrine therapy and CDK4/6 inhibition in ER+ breast cancer 36 samples shares jnk
- GSE265762 Individual RNA-seq for different prostate cancer cells and Lucap145.2 PDX treated by JQ1, AZD5153,ENZ or by FOXA1 and BRD4 gene knockdown 20 samples shares brd4
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.