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Type I interferon signaling induces melanoma cell-intrinsic PD-1 and its inhibition antagonizes immune checkpoint therapy

GSE253179 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 6 samples Submitted 2024/08/05 Platform GPL21103
Summary
This study focuses on cancer cell-intrinsic programmed cell death (PD-1) functional regulation by examining induction of PD-1 in melanoma cells via type I interferon receptor signaling. Treatment of mouse melanoma cells with IFN-alpha or IFN-beta led to chromatin opening at and STAT1 and IFN regulatory factor 9 (IRF9) binding to a PDCD1 enhancer motif.
Published in
Type I interferon signaling induces melanoma cell-intrinsic PD-1 and its inhibition antagonizes immune checkpoint blockade
Holzgruber J, Martins C, Kulcsar Z et al. · Nature communications 2024 · PMID 39187481 · doi:10.1038/s41467-024-51496-2
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Direct links to NCBI, no account and no request form: the whole study as GSE253179_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1064162 and SRA study SRP483409. Searching any of these in the dataset finder brings you back here.

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