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Sexual dimorphism in skin immunity is mediated by androgen-ILC2-dendritic cell axis [scRNA-seq]

GSE253294 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2024/04/09 Platform GPL19057
Summary
Males and females exhibit profound differences in immune responses and disease susceptibility. However, the factors responsible for sex differences in tissue immunity remain poorly understood. Here, we uncover a dominant role for type 2 innate lymphoid cells (ILC2) in shaping sexual immune dimorphism within the skin. Mechanistically, negative regulation of ILC2 by androgens leads to a reduction in dendritic cell (DC) accumulation and activation in males, and reduced tissue immunity. Collectively, this work uncovers an androgen-ILC2-DC axis in controlling sexual immune dimorphism. Moreover, this work proposes that tissue immune set-points are defined by the dual action of sex hormones and the microbiota, with sex hormones controlling the strength of local immunity and microbiota calibrating its tone.
Published in
Sexual dimorphism in skin immunity is mediated by an androgen-ILC2-dendritic cell axis
Chi L, Liu C, Gribonika I et al. · Science (New York, N.Y.) 2024 · PMID 38574174 · doi:10.1126/science.adk6200
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Also filed as BioProject PRJNA1064988 and SRA study SRP483824. Searching any of these in the dataset finder brings you back here.

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